Decal B12 Syrup Provides an ideal method of increasing calcium and during dentition

Decal B12
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Decal B12 Syrup

Company Name:

Amriya Pharmaceutical Ind.

Trade Name:

Decal B12 Syrup

Generic Name:

Calcium Levulinate
Vitamin D3
Vitamin B12


Each 100 ml syrup contains:
Active ingredients:
Calcium Levulinate                   1 gm
Vitamin D3                                20,000 I.U
Vitamin B12                               0.2 mg
Inactive ingredients:
Sucrose, Sodium methyl hydroxy benzoate, Sodium propyl hydroxy benzoate, Ethanol, Glycerin, Hydrochloric acid, Poloxamer 407, Butylated hydroxyanisole, Potassium sorbate, Tutti fmitti, Ponceau 4 R colour, Purified water.

Pharmaceutical Form:

Oral syrup


– Calcium is essential for bone formation and extra amounts are needed during adolescence.
– Vitamin D improves absorption and utilisation of calcium by regulating the body’s calcium phosphorus ratio.
– Vitamin B12 is essential to cell metabolism and assists in the synthesis of nucleic acid.


– Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine; also absorption is increased in calcium deficiency and during periods of high physiological requirement such as during childhood. 1,25-Dihydroxycholecalciferol
(calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is predominantly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails. Calcium crosses the placenta and is distributed into breast milk.
– There is no definite data available on the pharmacokinetics of vitamin D3.
– In presence of calcium, vitamin B12 is absorbed systemically in lower half of ileum. Initially, bound to intrinsic factor; this complex passes down intestine, binding to receptor sites on ileal mucosa.
Protein binding is high. Vitamin B12 is metabolized in the liver and primarily eliminated unchanged in the urine. Its half-life is 6 days.


– Provides an ideal method of increasing calcium intake in children only.
– During dentition.
– When resistance to illness is lowered by malnutrition or adverse seasonal conditions.

Dosage and Administration:

Age                                                         Dose
6 months-1 year                                 2.5 ml
> 1 year                                                 5 ml
– These doses should be taken once a day.
– Decal B12 Syrup can be taken with milk or water or directly from the spoon.


– Hypercalcaemia; metastatic calcification
– Anaphylactic reaction and other sensitivity reactions

Side Effects:

Sensitivity reactions are reported and these are extremely rare.

Drug Interactions:

– Bran decreases the gastrointestinal absorption of calcium, and may therefore decrease the efficacy of calcium supplements. Corticosteroids also reduce calcium absorption. Calcium salts reduce
the absorption of a number of other drugs such as bisphosphonates, fluoride, some fluoroquinolones, and tetracyclines; doses should be separated by at least 3 hours.
– Vitamin 0 requirements possibly increased when given with antiepileptics (as carbamazepine, phenytoin or primidone) or barbiturates.
– Absorption of vitamin B’2 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, and colchicine. Serum concentrations may be decreased by concurrent use of oral contraceptives. Manv of these interactions are unlikely to be of clinical significance but should be taken into account
when performing assays for blood concentrations. Parenteral chloramphenicol may attenuate the effect of vitamin B’2 in anaemia.

Pregnancy and Lactation:

This medication is not intended for pregnant and lactating women.

Precautions and Warnings:

Take care to ensure correct dose in infants.


– There is no upper tolerable intake for vitamin B’2 as it is a water soluble vitamin.
– A normal heatthy body can tolerate a calcium intake up to 2.5 gm daily.
– Doses that may exceed 250 micrograms (10,000 IU) daily of vitamin 0 may cause undesired effects.


A carton box containing a plastic bottle of 120 ml syrup.


Store at a temperature not exceeding 30°C.

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