Fladazole for treatment of amebiasis trichomoniasis and giardiasis

Fladazole
 
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Fladazole secnidazole

For Treatment of Amebiasis, Trichomoniasis and Giardiasis

Composition :

Each tablet contains:
Secnidazole     500 mg.

Properties :

Secnidazole is a 5-nitroimidazole derivative. It has antiparasitic activity against Entameba histolytica, Trichomonas vaginalis and Giardia lamblia.

Pharmacokinetics :

Secnidazole (Fladazole@) is readily absorbed after administration by mouth. Peak plasma concentrations are achieved within 3 hours after a single oral dose of 2 gm (4 tablets). It is mainly eliminated in urine. Plasma half-life is about 24
hours.

Indications :

–  Intestinal amebiasis
–  Hepatic amebiasis
– UrogeoitaUrichomooiasis
–  Giardiasis

Contraindications :

History of hypersensitivity to imidazole derivatives Pregnancy or lactation     .

Side Effects :

Occasionally, it may cause some G.IT. disorders, e.g. nausea, vomiting, abdominal cramps and an unpleasant metallic taste. In rare cases, moderate
leucopenia may occur which disappears after treatment discontinuation.

Precautions :

– Avoid administration with patients who had blood dyscrasias.
–  Avoid alcohol consumption during treatment with secnidazole.

Drug interactions:

–  Do not associate with disulfiram as it may lead to delirium or mental confusion.
–  Adjust oral anticoagulant dosage during secnidazole treatment

Dosage :

Acute intestinal amebiasis: 1-day treatment
Adults: 2 gm (4 tablets) as a single dose.
Children: 30 mg/kg in a single dose.
Chronic intestinal amebiasis (cystic form): 3-day treatment
Adults: 2 gm (4 tablets) in a single daily dose for 3 days.
Children: 30 mg/kg in a single daily dose for 3 days.
Hepatic amebiasis: 5-day treatment
Adults: 1.5 gm (3 tablets) in a single daily dose for 5
Children: 30 mg/kg in a single daily dose for 5 days. Urogenital trichomoniasis: 1-day treatment
Adults: 2 gm (4 tablets) as a single dose.
Giardiasis: 1-day treatment.
Adults: 2 gm (4 tablets) as a single dose.
Children: 30 mg/kg in a single dose.

N.B.:

To take the tablets at the beginning of the meal.

How Supplied :

Strips of 4 tablets in packs of 1 strip.
Keep all medicaments out of reach of children

Product of:

AMOUN PHARMACEUTICAL CO. SAE.
EI-Obour City, Cairo, Egypt.

فلادازول لعلاج حالات العدوى الأميبية والتريكوموناس وطفيل جيارديا

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