Flomox for broad spectrum antibiotic

flumox
 
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FLOMOX   VIALS 500 mg or 1000 mg

 Broad-Spectrum Antibiotic

Composition:

Each vial 500 mg contains:
Amoxycillin (as sodium salt) 250 mg; Flucloxacittin (as sodium s’:llt) 250 mg.
Each vial 1000 mg contains:
Amoxycillin (as sodium salt) 500 mg; Flucloxacillin (as sodium salt) 500 mg.

Properties:

FLUMOX® is a combination of two bactericidal penicillins: amoxycilin (broad-spectrum penicillin) and flucloxacillin (penicillinase-resistant penicillin), to produce a wider spectrum of activity. Flucloxacillin exerts a bactericidal action on penicillinase -producing microorganism including most staphylococci.This combination exhibits bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms including penicillinase and non penicillinase – producing Staphylococci, Streptococcus pyogenes, pneumoniae, and faecalis, Corynebacterillm diphtheriae, Clostridia s pp., Bacillus anthracis; H.influenzae, Moraxella (Branhamella) catarrhalis, N.gonorrheae and meningitidis, E.coli, Proteus mirabilis, Salmonella, Bordetella pertussis. and Bacteroides melaninogenicus.

Pharmacokinetics:

FLUMOX® (amoxycillin sodium and flucloxacillin sodium) vial is given by injection; peak plasma concentrations are achieved in about 30 minutes following intramuscular injection. Doupling the dose can double the plasma concentrations. FLUMOX® is widely distributed at varying concentrations in body tissues and fluids. FLUMOX® is metabolized to a limited extent and the unchanged drug and metabolites are excreted in the urine and bile within 6 – 8 hours.

Indications:

FLUMOX® is indicated in the treatment of a wide range of infections including:
Respiratory tract infections: Bronchitis, pneumonia and emphysema.
Ear, nose and throat infections: Otitis media, sinusitis, tonsillitis and pharyngitis
Gastro-intestinal tract infections: Enteritis, cholecystitis, typhoid and paratyphoid fever. Genito- urinary tract infections: Cystitis, pyelonephritis, prostatitis, gonorrhea, and puerperal sepsis.
• Skin and soft-tissue infections: Boils, carbuncles, abscesses, cellulitis, post-operative
wound infections, and intra- abdominal sepsis.
Bone infections: Osteomyelitis and septic arthritis.
Other infections: Septicaemia, endocarditis, peritonitis , biliary tract infections, and meningitis.

Dosage and Administration:

Adults: 0.5g • 1 g. every 6 – 8 hours.
Children: (2 -12 years):1I2 adult dose; children (less than 2 years):1/4 adult dose.
• Administration may be intramuscular, intravenous injection or infusion.
In severe infections, the vial may be given in infusion, every 4 – 6 hours.
For intramuscular injection, FLUMOX® vial 500 mg should be dissolved in 2 ml;
FLUMOX® vial 1000 mg should be dissolved in 4 ml of water for injection.
For intravenous injection, FLUMOX® vial 500 mg should be dissolved in 5 ml; but
FLUMOX® vial 1000 mg should be dissolved in 10 rnl of water for injection, given slowly over 3 – 4 minutes.
FLUMOX® vials should be injected immediately after reconstitution with distilled water.
FLUMOX® vial is stable with the commonty- used intravenous fluids at 2S·C, if infused over a maximum period of 6 hours.
• Solutions containing dextrose or other carbohydrates should be infused within
30 • 40 minutes and must be changed within 2 hours. Solutions containing sodium bicarbonate must be changed within 4 hours. FLUMOX® must not be mixed with blood products or proteinaceous fluids.

Precautions:

Doses should be reduced in severe renal impairment.

Contra-indications:

A known hypersensftivity to penicillins.

Side Effects :

As with other penicillins, side-effects are usually mild and transient including diarrhoea, indigestion and skin rashes.

Packagings:

FLUMOX® Vial 500 mg : Boxes of 1 or 50 or 100 vials each.
FLUMOX® Vial1oo0 mg : Boxes of 1 or 50 or 100 vials each.
Also available :FLUMOX® Capsules: 250 mg and 500 mg.
FLUMOX® Dry Mix : 250 mg/5ml .
IKeep out ach of children .To be used under medical supervision.

MANUFACTURED By :

E.I.P.I.CO.O.
EGYPTIAN INT. PHARMACEUTICAL INDUSTRIES CO.
TENTH OF RAMADAN CITY A. R. E.

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