Mosapride for heartburn, nausea, and vomiting caused by chronic gastritis

Mosapride for heartburn, nausea, and vomiting caused by chronic gastritis 2478562 2478 Mosapride for heartburn, nausea, and vomiting caused by chronic gastritis Mosapride for heartburn, nausea, and vomiting caused by chronic gastritis
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2.5 mg and 5 mg Film Coated Tablet

Generic name:

Mosapride citrate
Pharmaceutical form:

Film coated tablet


Each film coated tablet
Active ingredient:
Mosapride citrate 2.5 mg
Mosapride citrate 5 mg
Inactive ingredient:
Lactose monohydrate, microcrystalline cellulose, magnesium stearate, povidone, colloidal silicon dioxide, Talc uritied), .crosscarmellose sodium.

Pharmacodynamic action:

– Mosapride table stimulates serotonin receptors in the digestive tract and increases acetylcholine release in order to improve the function of enterokinase and gastric emptying,
– Mosapride is a selective 5-HT4 receptor agonist with no affinity to 5-HT 1 – 5-HT 2
– Mosapride improves esophageal motility for patient with (GERD).
– Mosapride increases esophageal bolus transit.
– Mosapride shortens gastric emptying time.
– Mosapride reduces acid reflux variables (assessed using ambulatory pH monitoring).


– After oral administration of single dose of Mosapride 5-40 mg, peak Mosapride concentration (Cmax) were reached after-I hour. Mean elimination half-lives(t It,) were 1.4 – 2.0 hours.
– Plasma Cmax (52.0 ng/ml) of the active M I metabolite occurred 0.5 hours after a single dose ofmosapride 40 mg. Elimination of M 1 (t It, = 4.3 hours).
– Mosapnde is excreted in urine and feaces in 48 hours after administration of a single dose of Mo sap ride 5 mg.


– Heartburn, nausea, and vomiting caused by chronic gastritis.
– As adjuvant therapy with orally gastrointestinallavage solution for barium enema x-ray examination,

Dosage and administration:

– General dosage regimen: I he reconunen<led usual dosage of Mosapride for adults is 5 .mg three times daily before or after meals.
– Missed dosage: Take the missed dose as soon as possible. However, if it is amlost time for the next dose, skip the missing dose and continue your-regular dosing schedule.
– Overdose: is you took much of this medicine (more than advised), check with your doctor.
– Other: Do not stop taking this medicine without doctor’s instructions.


– Hypersensitivity to Mosapride or any of the components.
– Patients with hemorrhage or digestive blockage.

Side effects:

– No serious adverse events were reported, however in only 2.71 % of patients who had received mosapridc for more than 2 week show abdominal pain, diarrhea, dry mouth, loose stool, rash, hives, nausea and feeling fullness, generalized fatigability and loss of appetite.
– Elevated triglycrides in 1.0%, of patients and elevated AST, ALT and GGT in 1.4% of patients may occur.
– Rarely veritricular tachycardia may occur in patient with hypokalaemia.
– Jaundice. liver-dysfunction and fulminating hepatitis may rarely occur.

Drug interactions:

– Concurrent use with gnti Cholinergic agents (atropine, butylscopolamine bromide) decreases Mosapride action,
– Concurrent use with ketoconazole, itraconamle, macrolide-&iHibiotics,..HlY.protease inhibitors) may increase
plasma concentration of Mosapride.

Pregnancy and lactation:

Not be be used in pregnancy and lactation.

Storage condition:

– Store in dry place at Terrnperature not exceeding 3O”C.
– Keep out of reach of children.
– Discard the remainder. Do not store.


Cartoon box containing 1.2.3 (AI/PVC) blisters each of 10 tablets and inner leaflet.

Patient information :

Not to be used without physician instructions.


Western pharmaceutical industries

موزابرايد لعلاج حرقان المعدة والغثيان والقئ الناتج عن التهاب المعدة المزمن

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