Omepak capsules

omepak
 
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Omepak capsules

Composition:
Omepak CapsulesEach capsule contains
Omeprazole……………… 20 / 40 mg

Properties:
Omepak promotes healing of ulcers of the stomach, duodenum, & esophagus.
It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/ potassium adenosine triphosphate, the so called the proton pump of the gastric parietal cell.

It is valuable in those whose peptic ulcer is not well controlled by H2 antagonists.

Omepak also enhances antibiotic activity against H pylori by raising gastric pH. Omepak is rapidly absorbed and is extensively bound (about 95%) to plasma protein. It is cleared by the circulation by hepatic metabolism and most of the metabolized are excreted in the urine.

Indications:
► Peptic ulcer
► Duodenal ulcer
► Gastro- Esophageal Reflux
► Zollinger-Ellisson syndrome

Use during pregnancy and lactation:
Omepak is used during pregnancy only if the potential benefit justifies the potential riskto the fetus. Because of the potential for serious adverse reaction in nursing infants from Omepak a decision should be made whether to discontinue nursing or to discontinue the drug taking of course into account the importance of the drug to the mother.

Dosage & route of administration & duration:
► Peptic ulcer and reflux oesophagitis
1 or 2 capsules daily as single dose for 4 to 8 weeks
► Zollinger-Ellisson syndrome
3 to 4 capsules and maybe increased up to 9 capsules daily in divided doses in long term treatment

Drug interaction:
Since Omepak interacts with cytochrome P 450 in vitro, inhibition of hepatic metabolism of certain drugs may be important. Although the clearance of diazepam is reduced by about 50%, Omepak has only minor effects on the elimination of single oral doses of phenytoin. It also increases the anticoagulant activity of warfarin

Side effects:
Omepak is well tolerated in treatment of patients with Zollinger-Ellisson syndrome with doses of 180-360mg/ day for up to 4 years had not caused any adverse or side effects.
Nausea, diarrhea, abdominal colic, paraesthesia, dizziness and headache have been stated to be generally mild, transient and not requiring a reduction in dosage.

Storage:
Keep away from heat, light, moisture, and at temperatures not exceeding 30ºC

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