Pridocaine local anaesthetic for topical use to produce surface anaesthesia of the skin

 
Pridocaine local anaesthetic for topical use to produce surface anaesthesia of the skin https://www.medicinep.com/wp-content/uploads/2021/01/Pridocaine.png 4384562 4384 Pridocaine local anaesthetic for topical use to produce surface anaesthesia of the skin Pridocaine local anaesthetic for topical use to produce surface anaesthesia of the skin
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Pridocaine Udocaine/Prilocaine

Composition :

Pridocaine cream contains: Lidocaine 2.5% & Prilocaine  2.5%.

Pharmacodynamics :

Pridocaine cream contains a combination of two local anaesthetics of the amide type, lidocaine and prilocaine. They act by causing a reversible block to conduction.of ne e impulses from sensory nerves along nerve fibres. This action results from an alteration of tile cell membrane permeability to ions.
Penetration and subsequent systemic absorption of this mixture is enhanced over use of each agent alone. Onset, depth and duration of dermal analgesia provided by this mixture depends primarily on duration of application.

Pharmacokinetics :

Systemic absorption appears to be minimal when applied to intact skin even after treating large areas or leaving the cream in place for many hours.

Indications :

1- Local anaesthetic for topical use to produce surface anaesthesia of the skin for:
– Minor dermatological procedures under occlusive dressing, e.g. needle insertion ana surgical treatment oflocalised lesions.
– Venepuncture for blood sampling, intravenous or arterial
cannulation.
– Dermal procedures on larger areas under occlusive dressing, e.g. split skin grafting.
2- For topical use on the genital mucosa to facilitate the removal
of warts in adults.

Side effects :

Transient paleness, redness and oedema have been reported.

Contraindications :

Known hypersensitivity to anaesthetics of the amide type.

Precautions :

Should not be applied to wounds, mucous membranes or in areas
of atopic dermatitis.
Should not be applied to genital mucosa in children.
Should not be applied to or near the eyes or middle ear.
Although the systemic availability ofprilocaine by percutaneous
absorption is low, caution should be exercised in patients with anaemia, congenital or acquired methaemoglobinaemia or patients on concomitant therapy known to produce such conditions.
Avoid in pregnancy and lactation.

Dosage & administration :

Anaesthesia before minor skin procedures including venepuncture :
Apply thick layer under occlusive dressing 1-5 hours before procedure (2-5 hours before procedures on large areas e.g. split
skin grafting).
Removal of warts from genital mucosa in adults, apply up to
109 5-10 minutes bcfare removal.

Presentation :

Pridocoine cream is supplied in tubes of 15 g each.
Store at temperature not exceeding 30°C, in dry place.
I Keep out of reach of children

Manufactured by :

GLOBAL NAPI PHARMACEUTICALS
6th of October City – EGYPT

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