Solvazinc for the treatment of zinc deficiency

 
Solvazinc for the treatment of zinc deficiency https://www.medicinep.com/wp-content/uploads/2020/11/Solvazinc.png 4344562 4344 Solvazinc for the treatment of zinc deficiency Solvazinc for the treatment of zinc deficiency
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Solvazinc

Composition :

Each capsule contains:
Zinc sulphate heptahydrate 220 mg (Equivalent to zinc elemental 50 mg)

Inactive ingredients: Microcrystalline cellulose, Colloidal silicon dioxide, Magnesium stearate and Capsule shell: Gelatin, titanium dioxide, quinolone yellow & carmoisine red.

Pharmacological action :

Pharmacodynamic properties:
Zinc plays a vital role in the activities of over 100 enzymes including carbonic anhydrase, alcohol dehydrogenase, alkaline phosphatase and RNA polymerase. It is also required to maintain structure in nucleic acids, protein and cell membranes and is involved in the function of the hormone insulin in the utilization of carbohydrates. It is necessary for normal rate of growth, development of the reproductive organs, normal function of the prostate gland and the healing of wounds and burns.

Pharmacokinetic properties:
Approximately 20 to 30% of dietary linc is absorbed primarily from the duodenum and ileum. The amount absorbed depends on the bioavailability of the food. Zinc is the most bioavailable from red meat and oysters.After absorption Zinc is bound in the intestine to the protein metaliothionine.Zinc is primarily eliminated (approximately 40%) in the faeces and to lesser extent in the urine
and perspiration.

Indications :

For the treatment of zinc deficiency which can occur in individuals on an inadequate diet, in malabsorption, with increased tissue loss due to trauma, burns and protein-losing conditions and during intravenous feeding.

Precautions & Warnings :

-Therapy should continue until clinical improvement occurs and be replaced by dietary measures unless there is severe malabsorption, metabolic disease or continuing zinc loss.

– Zinc capsules should be taken two hours before eating fibre containing foods and should not be taken within two hours of iron, copper or phosphorous supplements.
– Zinc levels may accumulate in acute renal failure.

Contraindications :

– Hypersensitivity to any component of the product.
– Copper deficiency.

Adverse actions :

– Gastro-intestinal disturbances such as dyspepsia, epigastric pain,
gastric irritation, gastritis, nausea, vomiting, diarrhoea, leukopenia
(fever, chills or sore throat) and neutropenia (continuing ulcers
and sores in mouths), headache, lethargy, irritation.

Pregnancy & lactation :

-Problems in humans have not been documented with intake of normal daily requirements.

-The safety of this product in human pregnancy has not been established. Zinc crosses the placenta and is present in breast milk. Therefore, like other drug preparations caution should be exercised in administering this product during pregnancy and lactation.

Drug interaction :

– Copper: l:arge doses of zinc inhibit the absorption of copper in the intestine.
– Tetracycline antibacterials: Zinc decreases the absorption of
tetracyclines by the formation of an insoluble chelate. The absorption of zinc may be reduced by tetracyclines; when both are being given an interval of at least three hours should be allowed.
– Quinolone antibacterials: Zinc may reduce the absorption of qumotones ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin.
– Penicillamine: The absorption of zinc may be reduced by penicillamine, also the absorption of penicillamine may be reduced by zinc.
– Calcium salts: The absorption of zinc may be reduced by calcium salts.
– Food: The absorption of zinc is reduced when it is taken concurrently with phytates (found in bran, whole grain breads), fibre containing foods or phosphorus containing medication and foods (milk or poultry).
– Iron: The absorption of zinc may be reduced by oral iron, also the absorption of oral iron may be reduced by zinc.
– Trientine: The absorption of zinc may be reduced by trientine, also the absorption of trientine may be reduced by zinc.

Dosage & administration :

Orally one capsule to be taken three times a day an hour before food or two hours after meal.
Children under 12 years: Not recommended.

Overdose :

Zinc sulfate is corrosive in overdosage. Symptoms are corrosion and
inflammation of the mucous membrane of the mouth and stomach, ulceration of the stomach followed by pertoration may occur. Gastric lavage and emesis should be avoided. Prolonged use of large doses may intertere with the absorption of iron and copper, leading to deficiency in these minerals, causing nausea, vomiting, headache, fever, malaise and abdominal pain. Excess intake may be treated with withdrawal of zinc and symptomatic therapy. The level of zinc can be diluted by drinking plenty of milk and water or administration of intramuscular or intravenous edetate calcium disodiurn at a dose of 50 to 75 mg per kg (mglkg) of body weight per day, in 3 to 6 divided doses, for up to 5 days.

Package :

– Cartoon box contains 1,2 or 3 (Aluminium! opaque PVC) strips each of 10 hard gelatin capsules with insert leaflet.

Storage :

– Store at a temperature not exceeding 300e in dry place.
– keep out of reach of children.

Manufactured by :

AI Esraa Pharmaceutical Optima

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