Each Capsule of Tabocine 100 contains: Doxycycline Hyclate equivalent to Doxycycline Anhydrous 100 mg.
Tabocine 100 is a brand name of Doxycycline Hyclate capsules which is a broad spectrum antibiotic. Synthetically derived from oxytetracycline. Doxycycline hyclate primarily acts as a bacteriostatic and is thought to exert an anti-microbial effect by the inhibition of protein synthesis. Doxycycline has a similar spectrum activity to tetracyclines. It is active against a wide range of Gram-positive and Gram-negative organisms such as: Spirochaets,
mycoplasma, brucella, rickettsia, actinomyces, leptospira and chlamydia. However, pseudomonas and certain strains of proteus, escherichia coli and bacteroides fragilis are generally resistant to doxycycline. Doxycycline has been found to be active against the asexual erythrocytic forms of plasmodium falciparum but not against gametocytes of plasmodium falciparum.
The special pffilfmacologiCBI profiles or-dOxycycline with a high absorption in the gastrointestinal tract, high penetration of the tissues and a long biological half-life make it possible to maintain a bacteriostatic blood and tissue concentration for 24 hours after a single dose. However, the major part of a dose of doxycycline is excreted unchanged. Doxycycline thus affords clinical advantages such as a single daily dosage for most patients and safe treatment for patients with impaired renal functions.
Infections caused by micro-organisms sensitive to doxycycline, acute pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, cholecystitis, tonsillitis, salpingitis, otitis, sinusitis, chronic bronchitiS, -pneumonia, actinomycosis, brucellosis (In conjunction with streptomycin), cholera, chloroquine resistant falciparum
malaria. Chlamydial infections such as: Non-gonococcal urethritis, ornithosis, psittacosis, trachoma, venereal lymphogranuloma. Pelvic inflammatory disease, pleural effusion, acne vulgaris, leptospirosis, mycoplasmal infections such as pneumonial mycoplasma.
Rickettsiosis such as: Epidemic typhus, endemic murine typhus, Q fever, Rocky mountain spotted fever, scrub typhus, tularemia.
The drug should not be given to patients hypersensitive to tetracyclines. Doxycycline is contraindicated in pregnancy, breast feeding, systemic lupus erythromatosus, porpnyMa and children below the age of 6 years owing to the risk of discolouration of permanent teeth.
The use of antibiotics may occasionally result in overgrowth of nonsusceptible organisms. Constant observation of the patient is essential. If resistant organisms appear, the antibiotic should be discontinued and appropriate therapy instituted. When treating venereal disease or when coexistent syphilis is suspected, proper diagnostic procedure including dark-field examinations should be
utilized. In all such cases monthly serological tests should be made for at least four months.
Administration of adequata amounts of fluid together with the dose, with the patient in an upright position, and well before retiring for the night is recommended to reduce the risk of esophageal irritation and ulceration. If gastric irritation occurs, it is recommended that doxycycline be given with food or milk. Studies indicate that the absorption of doxycycline is not markedly influenced by simultaneous ingestion of food or dairy products.
Interactions with other drugs :
Because the tetracyclines have been shown to depress plasma prothrombin’ activity, patients who are on anticoagulants therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is inadvisable to give doxycycline with-penicillin. Absorption of tetracyclines is impaired by iron-containing preparations and antacids containing aluminium, calcium, magnesium or bismuth as bismuth subsalicylate.
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline. The concurrent use of tetracyclines and methoxyflurane has been reported to result in fatal renal toxicity.
Dosage and Administration :
The dosage for adults is 100 mg every 12 hours for the first day, followed by 100 mg once a day, or twice a day when severe infection is present. The duration of treatment depends upon the character of the
– disease and the response-to therapy, however,it should-be
continued for 24-48 hours after symptoms have subsided.
Acne vulgaris: 50 mg daily for 6-12 weeks.
For treatment of chloroquine-resistant falciparum malaria:
200 mg daily for at least 7 days.
For prophylaxis of malaria: 100 mg daily in adults, for
children over 8 years old the dose is 2 mg/kg given once a day up to the adult dose.
Side Effects :
Due to complete absorption of doxycycline, gastrointestinal side effects are infrequently and less than other tetracyclines, The following adverse reactions have been observed: Nausea, vomiting, diarrhea, esophagitis, photosensitL’lily reaction (discontinue treatment with first evidence of skin erythema), headache, visual disturbances, pancreatitis, hepatotoxicity and pseudomembranous colitis may occur as with other antibiotics.
Consult your Physician or Pharmacist if any side effect is observed,
Pharmaceutical Precautions :
Keep at room temperature (15 – 30 ·C).
Do not use beyond the expiry date or if the product shows
any sign of deterioration.
Pack of 10 capsules.
Hospital packs are available.
Manufactured by :
TABUK PHARMACEUTICAL MANUFACTURING COMPANY, TABUK-SAUDI ARABIA,