2 mg Film Coated Tablet
Each film coated tablet contains: 2 mg tolterodine tartrate
Mechanism of action :
TOLTERODINE is a competitive. specific muscarinic receptor antagonist which exhibits a selectivity for the urinary bladder over salivary glands. Tolterodine has a high specificity for muscarinic receptors.
TOLTERODINE is rapidly absorbed. Both tolterodine and the 5-hydroxymethyl metabolite reach maximal serum concentrations 1-3 hours after dose administration
Food does not influence the exposure of the unbound tolterodine although the tolterodine levels increase when taken with food.
TOLTERODINE is indicated for the treatment of overactive bladder with symptoms of urinary urgency, frequency and/or urge incontinence.
TOLTERODINE is contraindicated in patients with:
⦁ Urine retention
⦁ Known hypersensitivity to tolterodine or its exciplents
⦁ Severe ulcerative colitis
⦁ Autonomic neuropathy
⦁ Pregnancy & lactadon: except in urgent case using adequate concentration.
Side effects :
TOL TERODINE may cause mild-to-moderate annmuscarinic effects, like dryness of the mouth, dyspepsia and reduced lacrimation.
The antimuscarinic effect ofTOLTERODINE may become more pronounced when administered to patients receiving fluoxetinc.-
Warnings and Precautions :
TOLTERODINE should be used with caution in the followiog patients:
o Patients at risk of urine retention
⦁ Patients with impaired hepatic function
⦁ Machines users and Driven: Since TOLTERODI ‘E may cause accommodation disturbances and influence reaction time.
Dosage and Administration :
-The TOLTERODINE recommended dose is 1 tablet 2mgtwice a day.
-In the case of’rroubtcs e side-effects the dose may be reduced from 2mg to I mg twice a day.
-The recommended dose is I mg twice a day for patients with impaired reduced renal function, impaired liver function, or receiving concomitant ketoconezole.
Overdosage with TOLTERODINE can potentially result in severe central anti muscarinic effects and should be treated accordingly.
Package & Storage :
Package: Box of3 blisters (each one contains 10 tablets).
Storage: To be stored in a cool dry place, away from light and in a temperature not exceeding 30°C.
Produced by :
Sabaa International Company-for pharmaceutical and Chemical industries S.A.E.
Keep all medicine out of reach of children