Cobal f for prevention of pregnancy complications

Cobal f

Cobal f
Mecobalamin 500 mcg
Folic acid 200 mcg

composition :

Each Cobal F film-coated tablet contains:
Mecobalamin 500 mcg
Folic acid 200 mcg
Inactive ingredients: Lactose monohydrate, maize starch, ethanol 99%, magnesium stearate and hydroxypropyl methylcellulose E5.


Cobal F is a combination of mecobalamin and folic acid. Mecobalamin, is a water-soluble vitamin B12. Vitamin B 12 occurs in the body mainly as methylcobalamin (mecobalamin), adenosylcobalamin (cobamamide) and
hydroxycobalamin. Mecobalamin, as one of the two active coenzyme forms of vitamin B 12 (the other being adenosylcobalamin), plays an important role
as a coenzyme of methionine synthetase in the transmethylation of
homocysteine to methionine. Mecobalamin removes the methyl group from methyltetrahydrofola to form tetrahydrofolate which participates in purine, pyrimidine, and nucleic acid synthesis. Folic acid (pteroylglutamic acid), member of the vitamin B group, is the parent compound for a large number of derivatives collectively known as folates. Folic acid stimulates production of red, white blood cells and platelets in certain-megaloblast-ic-an


Evidence indicates that mecobalamin is utilised more efficiently the
cyanocobalamin to increase level of vitamin B12. It is stored in th liver, excreted in the bile, and undergoes extensive enterohepatic recycling.
Human urinary excretion of mecobalamin is about one-third that of similar dose of cyanocobalamin, indicating greater tissue retentioi Folic acid is rapidly absorbed from the gastrointestinal tract, main! from the duodenum and jejunum. Folic acid administered therapeutically enters the portal circulation
largely.unchanged. The principal storage site of folate is the liver; it is also actively concentrated in the CSF. Folate metabolites are eliminated in the urine and folate in excess ( body requirements is excreted unchanged in the urine.
Folate is distributed into breast milk. Folic acid is removed by haemodialysis.


– Prevention of pregnancy complications such as: early abortion, low-birth weight, neural tube defects, pre-eclarnpsia, placental abruption, and maternal hyperhomocysteinaemia associated with increased risk of congenital heart disease.
– Treatment and prevention of folate deficiency state.
– Megaloblastic macrocytic anaemia.
– Malaise and fatigue.
– Reduces risk of cardiovascular disorders, as it decreases homocysteine level in the blood.
– In cases of inadequate nutrition, e.g. elderly people and vegetarian,
– Osteoporosis and lumbago.
– Male and female infertility caused by hypovitaminosis B12.

Side effects:

Mecobalamin and folic acid are generally well tolerated and no known toxicity.
Gastrointestinal disturbances such as loss of appetite, nausea, diarrhoea or other symptoms of gastrointestinal upsets may infrequently appear. Hypersensitivity reactions or skin rash may rarelyoccur.


Hypersensitivity reactions to mecobalamin, folic acid or any ingredient in the product.


Caution is advised in patients who may have folate-dependent tumours.

Dosage and administration:

Two to three tablets to be taken daily, or as prescribed by the physician.

Drug Interactions:

No drug interaction of major clinical significance has been reported with Mecobalamin. However, the gastrointestinal absorption of vitamin BI2 substances in general may be decreased by colchicine arninoglycoside, antibiotics, aminosalicylic acid and its salts, and by excessive alchohol intake lasting than 2 weeks.

Pregnancy and lactation:

Studies have not been done in humans. In animals, mecobalamin was not found teratogenic. Mecobalamin is distributed into breast milk .


Cobal F tablets are supplied in boxes of20 tablets each.
Store at temperature not exceeding 30°C, in dry place, away from light.
I Keep out of reach of children I

produced by :

2″” Industrial Zone, 6·of October City. Egypt

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